Langerin (CD207) Mouse Monoclonal Antibody [Clone ID: 808E10.01]

CAT#: DDX0360A488-100

Langerin (CD207) mouse monoclonal antibody, clone 808E10.01


USD 530.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 808E10.01
Applications FC, IF
Recommended Dilution Surface Flow cytometry, IF
Reactivities Human, Mouse
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen human Langerin-transfected eukaryotic cells
Specificity Human Langerin (extracellular epitope). 
Species cross-reactivity: Mouse.
Formulation PBS 50% glycerol
Label: Alexa Fluor 488
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Alexa Fluor 488
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name CD207 molecule
Background Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system.
(Valladeau J et al, 2002; J. Immunol., 168 : 782-779 ; Douillard P et al, 200; J. Invest. Dermatol., 125: 983–994).
Synonyms CLEC4K, Dendritic Cell Marker
Note Protocol: Langerin-gp120 blocking protocol:
Mock- and Langerin-transfected CHO cells are incubated with biotin-labelled gp160 (5μg/ml) and clone 808E10.01 at (1 to 10μg/ml) in PBS 45 min. at RT. Cells were washed in PBS 5min at 1600rpm, and stained with Streptavidin-PE 30 min at 4°C (DAKO). A last PBS wash is performed before Flow cytometry analysis.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.