Langerin (CD207) Mouse Monoclonal Antibody [Clone ID: 310F7.02/HD26]

CAT#: DDX0361A647-100

Langerin (CD207) mouse monoclonal antibody, clone 310F7.02/HD26

Product Images

IHC staining of human skin frozen section with clone 310F7 (DX0361)

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  FACS staining with 310F7.02 of cells derived from overnight culture of porcine skin biopsies permeabilized (B) or not (A).

Specifications

Product Data

• Clone Name: 310F7.02/HD26
• Applications: FC
• Recommended Dilution: Flow Cytometry
• Reactivities: Human, Mouse, Porcine, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: mouse Langerin-transfected eukaryotic cells
• Specificity: Mouse Langerin (intracellular epitope).
  Species cross- reactivity: rat, human, pig
• Formulation: PBS 50% glycerol
  Label: Alexa Fluor 647
• Concentration: lot specific
• Purification: QMA Hyper D ion exchange chromatography
• Conjugation: Alexa Fluor 647
• Storage: -20°C. KEEP CONTENTS STERILE: no preservative.
  Purified antibodies: avoid repeated freeze/thaw cycles.
  Coupled antibodies: glycerol protects from freezing.
• Gene Name: CD207 molecule
• Database Link:
  Entrez Gene 50489 Human
  UniProt ID Q9UJ71
• Background: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 2002 J. Immunol, 168 : 782-792) (Douillard P et al, 2005 J Invest Dermatol, 125: 983–994)
• Synonyms: CLEC4K, Dendritic Cell Marker