Langerin (CD207) Rat Monoclonal Antibody [Clone ID: 929F3.01]

CAT#: DDX0362A488-100

Langerin (CD207) rat monoclonal antibody, clone 929F3.01


USD 530.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 929F3.01
Applications FC, IF, IHC
Recommended Dilution DDX0362P-50 / DDX0362P-100 Purified: IF, IHC formol-paraffin, Flow cytometry.
DDX0362A488-50 / DDX0362A488-100 Alexa-fluor® 488: IF, IHC , Flow cytometry.

Usage recommendation:

*This monoclonal antibody may be used between 5-20 μg/ml.
*Optimal dilution should be determined by each laboratory for each application. 
*Coupled antibody: to maintain RT before use.
Reactivities Human, Mouse, Porcine, Rat
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen human Langerin-transfected eukaryotic cells
Specificity Human Langerin.
Species cross-reactivity: Rat, Mouse, Swine.
Formulation Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol.
Label: Alexa Fluor 488
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Alexa Fluor 488
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name CD207 molecule
Background Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck’s granule. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin expression has not been reported outside the DC system. Human Langerin is involved in the processing of mycobacterial glycolipids leading to antigen presentation to CD1a-restricted T cells. Human Langerin binds the gp120 of HIV. (Valladeau J et al, 2002 J. Immunol, 168 : 782-792; Douillard P et al, 2005 J Invest Dermatol, 125: 983–994; Chorro L. et al, J Exp.Med., 2010, 206 (13), 3089-3100).
Synonyms CLEC4K, Dendritic Cell Marker
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.