Langerin (CD207) Mouse Monoclonal Antibody [Clone ID: DCGM4/122D5.03]

CAT#: DDX0363B-100

Langerin (CD207) mouse monoclonal antibody, clone DCGM4/122D5.03


USD 340.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name DCGM4/122D5.03
Applications FC, IHC, WB
Recommended Dilution DDX0363P-50 DDX0363P-100 Purified: Internalization, Flow cytometry, IHC.
DDX0363A488-50 DDX0363A488-100 Alexa-fluor®488: Flow cytometry, IF.
DDX0363A546-50 DDX0363A546-100 Alexa-fluor®546: IF.
DDX0363A647-50 DDX0363A647-100 Alexa- fluor®647: Flow cytometry.
DDX0363B-50 DDX0363B-100 Biotin: Western blot. 

Usage recommendation:
*This monoclonal antibody may be used between 5-20 μg/ml.
*Optimal dilution should be determined y each laboratory for each application.
*Coupled antibody: to maintain RT before using.
Reactivities Canine, Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen In vitro-derived human DCs from CD34+ cells in GM-CSF+TNFα
Specificity Human Langerin (extracellular epitope in Carbohydrate Recognition domain). 
Species cross-reactivity: Dog.
Formulation Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol.
Label: Biotin
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Biotin
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name CD207 molecule
Background Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck’s granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 ; Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)
Synonyms CLEC4K, Dendritic Cell Marker
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.