CD49b (ITGA2) Human Monoclonal Antibody [Clone ID: F2H11]

CAT#: DDX9021P-100

CD49b (ITGA2) human monoclonal antibody, clone F2H11


USD 600.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name F2H11
Applications ELISA, FC, IF
Recommended Dilution Platelet phenotyping by flow cytometry, IF, ELISA, platelet aggregation studies.
Usage recommendation:
*This monoclonal antibody may be used between 5-25μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before use.
Reactivities Human
Host Human
Isotype IgG1
Clonality Monoclonal
Immunogen CD40 activated and EBV immortalized human B lymphocytes.
Specificity HPA5b (does not bind to HPA5a differing by a single amino acid).
Formulation 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
State: Purified
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Unconjugated
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name integrin subunit alpha 2
Background Neonatal AlloImmune Thrombocytopenia (NAIT) is the commonest cause of severe isolated thrombocytopenia in the foetus and newborn. In Caucasians, 97% of NAIT are caused by HPA-1a or HPA- 5b alloantibodies. By combining CD40 activation and Epstein-Barr virus transformation of B cells isolated from a woman with high titre of anti -HPA-5b alloantibodies. F2H11 human monoclonal antibody is highly specific (does not bind to HPA5a) , and allows a rapid and accurate phenotyping of pregnant women as well as selection of blood donors. (Mérieux Y, Rigal D, Pin JJ, XVIIth Regional Congress, International Society of Blood Transfusion, Madrid 2007 ; Guillot-Chene P, Lebecque S, Rigal D, Annales Pharmaceutiques Françaises, 06/2009, 67 (3) 182-6).
Synonyms human platelet antigen 5b
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.