CD49b (ITGA2) Human Monoclonal Antibody [Clone ID: B4F12]

CAT#: DDX9022A488-100

CD49b (ITGA2) human monoclonal antibody, clone B4F12


USD 730.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name B4F12
Applications FC, IF
Recommended Dilution IF, ELISA, preferential detection of activated platelet by flow cytometry, platelet aggregation studies. 
Usage recommendation:
*This monoclonal antibody may be used between 5-25μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before use.
Reactivities Human
Host Human
Isotype IgG1
Clonality Monoclonal
Immunogen CD40 activated and EBV immortalized human B lymphocytes
Specificity GPIa-IIa preferentially on acitvated platelets.
Formulation 100 μg in 200 μl / 50 μg in 100 μl PBS 50% glycerol
Label: Alexa Fluor 488
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Alexa Fluor 488
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name integrin subunit alpha 2
Background Neonatal AlloImmune Thrombocytopenia (NAIT) is the commonest cause of severe isolated thrombocytopenia in the foetus and newborn. In Caucasians, 97% of NAIT are caused by HPA-1a or HPA- 5b alloantibodies. B4F12 was isolated after combination of CD40 activation and Epstein-Barr virus transformation of B cells isolated from a woman with high titre of anti -HPA-5b alloantibodies. B4F12 human monoclonal antibody recognizes GPIa-IIa preferentially on activated human platelets (Mérieux Y, Rigal D, Pin JJ, XVIIth Regional Congress, International Society of Blood Transfusion, Madrid 2007 ; Guillot-Chene P, Lebecque S, Rigal D, Annales Pharmaceutiques Françaises, 06/2009, 67 (3) 182-6).
Synonyms Integrin alpha-2, ITGA-2, VLA-2 alpha, VLA2, GPIa, Collagen Receptor
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.