CD49b (ITGA2) Human Monoclonal Antibody [Clone ID: B4F12]

CAT#: DDX9022P-100

CD49b (ITGA2) human monoclonal antibody, clone B4F12


USD 600.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name B4F12
Applications ELISA, FC, IF
Recommended Dilution IF, ELISA, preferential detection of activated platelet by flow cytometry, platelet aggregation studies. 
Usage recommendation:
*This monoclonal antibody may be used between 5-25μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before use.
Reactivities Human
Host Human
Isotype IgG1
Clonality Monoclonal
Immunogen CD40 activated and EBV immortalized human B lymphocytes
Specificity GPIa-IIa preferentially on acitvated platelets.
Formulation 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
State: Purified
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Unconjugated
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name integrin subunit alpha 2
Background Neonatal AlloImmune Thrombocytopenia (NAIT) is the commonest cause of severe isolated thrombocytopenia in the foetus and newborn. In Caucasians, 97% of NAIT are caused by HPA-1a or HPA- 5b alloantibodies. B4F12 was isolated after combination of CD40 activation and Epstein-Barr virus transformation of B cells isolated from a woman with high titre of anti -HPA-5b alloantibodies. B4F12 human monoclonal antibody recognizes GPIa-IIa preferentially on activated human platelets (Mérieux Y, Rigal D, Pin JJ, XVIIth Regional Congress, International Society of Blood Transfusion, Madrid 2007 ; Guillot-Chene P, Lebecque S, Rigal D, Annales Pharmaceutiques Françaises, 06/2009, 67 (3) 182-6).
Synonyms Integrin alpha-2, ITGA-2, VLA-2 alpha, VLA2, GPIa, Collagen Receptor
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.