Serum Amyloid A (SAA1) Mouse Monoclonal Antibody [Clone ID: 607]

CAT#: DM1004HRP

Serum Amyloid A (SAA1) mouse monoclonal antibody, clone 607, HRP


USD 735.00

2 Weeks*

Size
    • 200 ul

Product Images

Specifications

Product Data
Clone Name 607
Applications ELISA
Recommended Dilution ELISA: This HRP-conjugated monoclonal antibody can be used as a tracer/detection antibody in sandwich ELISA applications for human SAA detection in combination with a capture antibody Cat.-No DM1002.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Highly purified recombinant Human SAA (MW: 12 kDa)
Specificity This monoclonal antibody reacts with natural and recombinant Human SAA.
Does not show any cross-reaction with other human cytokines or growth factors tested such as IL-1β, IL-8, MCAF, TGF-β and EGF.
Formulation 0.01M PBS, pH 7.0±0.1 in 50% Glycerol
Label: HRP
State: Liquid purified IgG fraction
Label: Horseradish Peroxidase
Purification Affinity Chromatography on Protein G
Conjugation HRP
Storage Upon receipt, store (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name serum amyloid A1
Background The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP.
SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis.
Synonyms SAA1, SAA2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.