PSMA (FOLH1) Mouse Monoclonal Antibody [Clone ID: Y-PSMA2]

CAT#: DM1038

PSMA (FOLH1) mouse monoclonal antibody, clone Y-PSMA2, Purified

Specifications

Product Data

• Clone Name: Y-PSMA2
• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Crude membrane protein preparation from pooled prostate malignant carcinoma from China.
• Specificity: This antibody is reactive to PSMA expressed LNCap cell lines.
  Little or no cross-reactivity to benign prostate hyperplasia (BPH) or to normal prostatic tissue.
• Formulation: 0.01M PBS, pH 7.0
  State: Purified
  State: Lyophilized purified IgG fraction
  Stabilizer: None
  Preservative: None
• Reconstitution Method: Restore with double distillated water to adjust the final concentration to 1.0 mg/ml.
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 2346 Human
  UniProt ID Q04609
• Background: PSMA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.
• Synonyms: Glutamate carboxypeptidase 2, Folate hydrolase 1, Prostate-specific membrane antigen, FOLH, NAALAD1, PSM, GCP2, NAALAdase
• Note: Predicted Molecular weight: 84 kDa.