GDF15 (N-term) Mouse Monoclonal Antibody [Clone ID: ME-6D10]

CAT#: DM1224

GDF15 (N-term) mouse monoclonal antibody, clone ME-6D10, Purified


USD 380.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name ME-6D10
Applications ELISA, FC, WB
Recommended Dilution Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Flow Cytometry: 1.2 µg/106 cells.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Genetic immunisation with cDNA encoding amino acids 30-194 (N-term) of MIC-1 proprotein.
Specificity Recognizes Human Macrophage Inhibitory Cytokine-1 (MIC-1). 
Other species not tested.
Formulation Phosphate buffered saline, pH 7.2 without preservatives
State: Purified
State: Liquid purified IgG fraction
Concentration 2.0 mg/ml
Purification Affinity Chromatography on Protein G
Gene Name Homo sapiens growth differentiation factor 15 (GDF15)
Background Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-ß superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance (1). MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25-kDa disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines (1,2). MIC-1 is involved in tumour pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumours (3).
Synonyms GDF-15, MIC1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, MIC-1, Prostate differentiation factor, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1
Reference Data
Protein Families Druggable Genome, Secreted Protein

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.