Eph receptor A2 (EPHA2) Mouse Monoclonal Antibody [Clone ID: GM5H5]

CAT#: DM1226

Eph receptor A2 (EPHA2) mouse monoclonal antibody, clone GM5H5, Purified


USD 380.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name GM5H5
Applications ELISA, FC, IF, WB
Recommended Dilution Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Flow cytometry: 1.2 µg/10e6 cells.
Immunofluorescence: 1 µg/10e6 cells.
ELISA (detection): With clone LA-4E7-D2 as capture antibody.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Genetic immunisation with cDNA encoding Human EphA2
Specificity Recognizes EphA2 receptor tyrosine kinase (EphA2).
Formulation Phosphate buffered saline, pH 7.2
State: Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Affinity Chromatography on Protein G.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens EPH receptor A2 (EPHA2)
Background EphA2 (Eph receptor tyrosine kinase A2) belongs to the Eph tyrosine receptor familiy, the largest receptor tyrosine kinase family of transmembrane proteins. It encodes a 130 kDA transmembrane protein which is primarily found in adult human epithelial cells (1). Eph receptors and their ephrin ligands are important mediators of cell-cell communication and play roles in embryonic patterning, neuronal targeting, and vascular development during normal embryogenesis (2,3). The Eph family of receptor tyrosine kinases is frequently overexpressed in a wide variety of cancers and tumor cell lines. In particular, EphA2 is overexpressed in prostate, lung and colon cancers and 40% of breast cancers and it represent an attractive potential target for drug design (3,4).
Synonyms Ephrin type-A receptor 2, Epithelial cell kinase, Eph receptor A2
Note SDS-PAGE analysis: The antibody was purified by protein G affinity chromatography from cell culture supernatants and verified by SDS-Page (Figure.3).
Reference Data
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Axon guidance

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.