CEACAM5 (CEACAM1/5) Mouse Monoclonal Antibody [Clone ID: 4/3/17]

CAT#: DM1228

CEACAM5 (CEACAM1/5) mouse monoclonal antibody, clone 4/3/17, Purified


USD 380.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 4/3/17
Applications ELISA, FC, IF, IHC, WB
Recommended Dilution ELISA: 1/200-1/400.
Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Flow Cytometry: 1.2 µg/106 cells.
Immunohistochemistry on Cryosections: 1-2 µg/106 cells.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Immunisation with extracted protein of CEACAM5.
Specificity Recognizes CEACAM1, 5 (BGP, CEA, CD66a/e).
Formulation PBS, pH 7.2
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Affinity Chromatography on Protein G
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immuno-globulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells (3). The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria (1).
Synonyms Carcinoembryonic antigen, BGP, CEA, CEACAM1, CEACAM5, CD66a,e
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.