CCR4 Mouse Monoclonal Antibody [Clone ID: KH-4F5]
Other products for "CCR4"
Specifications
Product Data | |
Clone Name | KH-4F5 |
Applications | ELISA, FC, IF, WB |
Recommended Dilution | Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow cytometry: 1.2 µg/106 cells. Immunofluorescence: 1 µg/106 cells. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Immunisation with Human CCR4 peptide. |
Specificity | Recognizes Human CCR4. Other species not tested. |
Formulation | Phosphate buffered saline, pH 7.2 State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein G |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens C-C motif chemokine receptor 4 (CCR4) |
Database Link | |
Background | CCR4 (CC chemokine receptor 4) belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane-bound molecules composed of 7-transmembrane domains and are coupled to G-proteins (1,2). CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4(+) thymocytes especially in TH2- and regulatory T-cells (3,4). It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways (2,5). |
Synonyms | C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CMKBR4, K5-5 |
Note | SDS-PAGE analysis: The antibody was purified by protein G affinity chromatography from cell culture supernatants and verified by SDS-Page (Figure.3). |
Reference Data | |
Protein Families | Druggable Genome, GPCR, Transmembrane |
Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction |
Documents
Product Manuals |
FAQs |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.