MCP3 (CCL7) Mouse Monoclonal Antibody [Clone ID: 113]

CAT#: DM2035HRP

MCP3 (CCL7) mouse monoclonal antibody, clone 113, HRP


USD 590.00

2 Weeks*

Size
    • 200 ul

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Specifications

Product Data
Clone Name 113
Applications ELISA
Recommended Dilution ELISA: This MCP3 antibody HRP-conjugated can be used as a Tracer/Detection Antibody in Sandwich ELISA applications for human MCP-3 detection in combination with a Capture antibody (Cat#DM2039)
Suggested Capture Coating Dose: 3 µg/well
Substrate: TMB
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified Recombinant Human Monocyte Chemotactic Protein-3 (MCP-3).
Specificity Reactive with natural and recombinant human MCP-3.
Does not show any cross reaction with other Human Cytokines or growth factors tested such as IL1 beta, IL-8, MCAF, SAA and EGF
Formulation 0.01M PBS, pH 7.0 ± 0.1 in 50% Glycerol and 0.01% Thimerosal as a bacteriostat
Label: HRP
State: Liquid purified IgG fraction
Label: Horseradish Peroxidase
Purification Affinity Chromatography on Protein G.
Conjugation HRP
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens chemokine (C-C motif) ligand 7 (CCL7)
Background Macrophage/monocyte chemotactic protein-3 (MCP-3), like other two closely related chemokines (MCP1 and MCP-2), is chemotactic to monocytes, but not to neutrophils. MCP-3 showed 78% sequence homology with MCP-1 and 58% sequence homology with MCP-2. The primary receptor for MCP-3 is D6. MCP-3 also competes with MCP-1 to bind to CCR10, and competes with Rantes and MIP-1α to bind to CCR1. MCP-3 stimulates macrophage to secrete proteases. A variety of cancer cell lines express MCP-3, suggesting a role in tumor invasion and metastasia.
Synonyms Small-inducible cytokine A7, CCL-7, MCP-3, C-C motif chemokine 7, SCYA6, SCYA7, NC28
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.