MCP3 (CCL7) Mouse Monoclonal Antibody [Clone ID: 113]

CAT#: DM2035HRP

MCP3 (CCL7) mouse monoclonal antibody, clone 113, HRP

Specifications

Product Data

• Clone Name: 113
• Applications: ELISA
• Recommended Dilution: ELISA: This MCP3 antibody HRP-conjugated can be used as a Tracer/Detection Antibody in Sandwich ELISA applications for human MCP-3 detection in combination with a Capture antibody (Cat#DM2039)
  Suggested Capture Coating Dose: 3 µg/well
  Substrate: TMB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified Recombinant Human Monocyte Chemotactic Protein-3 (MCP-3).
• Specificity: Reactive with natural and recombinant human MCP-3.
  Does not show any cross reaction with other Human Cytokines or growth factors tested such as IL1 beta, IL-8, MCAF, SAA and EGF
• Formulation: 0.01M PBS, pH 7.0 ± 0.1 in 50% Glycerol and 0.01% Thimerosal as a bacteriostat
  Label: HRP
  State: Liquid purified IgG fraction
  Label: Horseradish Peroxidase
• Purification: Affinity Chromatography on Protein G.
• Conjugation: HRP
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens chemokine (C-C motif) ligand 7 (CCL7)
• Database Link:
  Entrez Gene 6354 Human
  UniProt ID P80098
• Background: Macrophage/monocyte chemotactic protein-3 (MCP-3), like other two closely related chemokines (MCP1 and MCP-2), is chemotactic to monocytes, but not to neutrophils. MCP-3 showed 78% sequence homology with MCP-1 and 58% sequence homology with MCP-2. The primary receptor for MCP-3 is D6. MCP-3 also competes with MCP-1 to bind to CCR10, and competes with Rantes and MIP-1α to bind to CCR1. MCP-3 stimulates macrophage to secrete proteases. A variety of cancer cell lines express MCP-3, suggesting a role in tumor invasion and metastasia.
• Synonyms: Small-inducible cytokine A7, CCL-7, MCP-3, C-C motif chemokine 7, SCYA6, SCYA7, NC28

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway