CD10 (MME) Mouse Monoclonal Antibody [Clone ID: 56C6]

CAT#: DM240

CD10 (MME) mouse monoclonal antibody, clone 56C6, Supernatant

Specifications

Product Data

• Clone Name: 56C6
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Embedded Sections: Use 1/20-1/30 dilution in an ABC method.
  High temperature antigen unmasking is required prior to immunostaining of formalin fixed paraffin embedded tissue sections.
  Incubation Time: 30 minutes at RT.
  Positive Control: Tonsil.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to the external domain of the CD10 glycoprotein
• Specificity: This antibody is specific to human CD10 antigen of 100 kD, also known as common acute lymphocytic leukemia antigen (CALLA).
  Cellular Localization: Cell membrane.
• Formulation: State: Supernatant
  State: Liquid Tissue Culture Supernatant containing Sodium Azide as preservative.
• Storage: Store the antibody undiluted at 2-8°C
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: membrane metallo-endopeptidase
• Database Link:
  Entrez Gene 4311 Human
• Background: CD10, also known as the Common Acute Lymphocytic Leukemia Antigen (CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.
  The CD10 antigen of 100 kD has been identified on the surface of early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue.
• Synonyms: MME, EPN, Neutral endopeptidase 24.11, Neutral endopeptidase, NEP, Enkephalinase, Atriopeptidase, CALLA