VEGF Receptor 2 (KDR) Mouse Monoclonal Antibody [Clone ID: KDREIC]

CAT#: DM3502B

VEGF Receptor 2 (KDR) mouse monoclonal antibody, clone KDREIC, Biotin


USD 365.00

2 Weeks*

Size
    • 50 ug

Product Images

Specifications

Product Data
Clone Name KDREIC
Applications ELISA, FC, IHC, WB
Recommended Dilution ELISA: 1-10 µg/ml.
Western Blot:
2-5 µg/ml.
Immunofluorescence/Immunohistochemistry: 6-30 µg/ml.
Flow Cytometry and cell sorting: 2-5 µg/ml.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant Human soluble extracellular KDR (D7) (110 kDa) (Cat.-No DA3530)
Specificity The monoclonal antibody will detect native Human VEGFR-2/KDR in ELISA experiments and on the surface of different Human cell types. Other species not tested.
Formulation PBS, pH 7.4
Label: Biotin
State: Lyophilized purified IgG fraction
Stabilizer: 50x BSA
Preservative: 0.02% Sodium Azide
Reconstitution Method Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
Purification Affinity Chromatography on Protein G
Conjugation Biotin
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Synonyms VEGFR2, FLK1, KDR, VEGF Receptor 2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.