VEGFC Mouse Monoclonal Antibody [Clone ID: 107F10]

CAT#: DM3528

VEGFC mouse monoclonal antibody, clone 107F10, Purified

Product Images

Western analysis of recombinant human VEGF-C derived from insect cells using., a monoclonal antibody directed against recombinant human/rat VEGF-C.

Specifications

Product Data

• Clone Name: 107F10
• Applications: ELISA, WB
• Recommended Dilution: ELISA: 2-10 µg/ml.
  Western Blot: 1-5 µg/ml.
• Reactivities: Human, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant Human VEGF-C protein (Cat.-No AR01001PU-N)
• Specificity: This antibody detects VEGF-C in Western Blots.
  No cross-reactivity is shown with VEGF-A.
• Formulation: PBS without preservatives or stabilizers
  State: Purified
  State: Lyophilized (0.2 µm filtered) purified IgG fraction
• Reconstitution Method: Restore in sterile water to a concentration of 0.1-1.0 mg/ml. Centrifuge vial prior to opening.
• Purification: Protein G Affinity Chromatography
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
• Stability: Shelf life: one year from despatch.
  After reconstitution the antibody can be stored undiluted at 2-8°C for up to two weeks
  or (in aliquots) at -20°C for six months.
  Avoid repeated freezing and thawing.
  
  
• Database Link:
  Entrez Gene 7424 Human
• Background: VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A.
• Synonyms: VEGFC, VRP, Vascular endothelial growth factor C, Vascular endothelial growth factor-related protein, Flt4 ligand