Dcn Rat Monoclonal Antibody [Clone ID: 9A38]

CAT#: DM3538P

Dcn rat monoclonal antibody, clone 9A38, Purified

Specifications

Product Data

• Clone Name: 9A38
• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Purified Mouse Recombinant Decorin
• Specificity: This antibody detects Mouse Decorin in Western blotting.
• Formulation: 0.2 μm filtered PBS solution
  State: Purified
  State: Lyophilized purified IgG fraction from Culture Supernatant
• Reconstitution Method: Restore with 0.2 ml sterile PBS and the final concentration is 0.5 mg/ml.
• Purification: Protein A/G affinity chromatography
• Database Link:
  Entrez Gene 13179 Mouse
• Background: Secreted chondroitin/dermatan sulfate proteoglycan belonging to the class I small leucine-rich proteoglycan family (SLRP). All SLRP family members are characterized by the Nterminal and C terminal cysteine rich regions, which flank the central region containing 1012 tandem leucinerich repeats. In mouse Decorin, the glycosaminoglycan chain is Olinked to Ser34 in the Nterminal disulfide bridged loop. Decorin binds to fibronectin, TGFβ, type I and type II collagen. The binding of Decorin to these molecules is mediated via the core protein. Decorin plays a role in maintaining collagen fibrillogenesis. Depending on the cell context, Decorin can either block or augment the bioactivity of TGFβ Decorin induces growth suppression by activation of a signaling pathway that culminates in the blockade of the cell cycle machinery. Decorin can also induce fibroblast cytoskeletal and signalling changes that results in an increased cell migration (1 2).
• Synonyms: DCN, SLRR1B, Bone proteoglycan II, PG-S2, PG40