Lgals1 Rat Monoclonal Antibody [Clone ID: 9J26]

CAT#: DM3545P

Lgals1 rat monoclonal antibody, clone 9J26, Purified

Specifications

Product Data

• Clone Name: 9J26
• Applications: IHC, WB
• Recommended Dilution: Western Blot (1/500-1/1000).
  Immunohistochemistry on Frozen Sections (1/50-1/200).
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Purified Recombinant Mouse Galectin-1
• Specificity: This antibody detects Mouse Galectin-1. Other species not tested.
• Formulation: 0.2 µm filtered solution in PBS without preservatives or stabilizers
  State: Purified
  State: Lyophilized purified IgG fraction from Cell Culture Supernatant
• Reconstitution Method: Restore with 200 µl sterile PBS and the final concentration is 500 µg/ml.
• Purification: Protein A/G Affinity Chromatography
• Database Link:
  Entrez Gene 16852 Mouse
• Background: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin 1 may act as an autocrine negative growth factor that regulates cell proliferation. It also may regulate cell apoptosis and cell differentiation. It binds beta-galactoside, CD45, CD3 and CD4.
  Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Some galectins exist in multiple isoforms due to alternative splicing. Individual galectins differ in their tissue distribution and in their carbohydrate-binding specificities. Galectin 1 inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. It is found in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney, placenta and hematopoietic cells.
• Synonyms: LGALS1, Galectin1, Lectin galactoside-binding soluble 1, Beta-galactoside-binding lectin L-14-I, Lactose-binding lectin 1, S-Lac lectin 1, Galaptin, 14 kDa lectin, HPL, HBL, MAPK-activating protein PM12