Galectin-3 Rat Monoclonal Antibody [Clone ID: 5L36]

CAT#: DM3546P

Galectin-3 rat monoclonal antibody, clone 5L36, Purified

Specifications

Product Data

• Clone Name: 5L36
• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Purified Mouse Recombinant Galectin-3
• Specificity: This antibody detects Mouse Galectin-3. Other species not tested.
• Formulation: PBS
  State: Purified
  State: Lyophilized purified IgG fraction from Culture Supernatant
• Reconstitution Method: Restore with 200 µl sterile PBS and the final concentration is 500µg/ml.
• Purification: Protein A/G Affinity Chromatography
• Background: Galectins are a new family of animal lectins which appear to exhibit a variety of biological functions. Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties.
  Galectin 3 is one of the more extensively studied members of this family and is a 30 kDa protein. Due to a C-terminal carbohydrate binding site, Galectin 3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homooligomerized. Galectin 3 is normally distributed in epithelia of many organs, in various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins.
• Synonyms: Mac-2, Lgals3, GAL3, GALBP, CBP35, L-31