Igfbp5 Rat Monoclonal Antibody [Clone ID: 12C23]

CAT#: DM3561P

Igfbp5 rat monoclonal antibody, clone 12C23, Purified

Specifications

Product Data

• Clone Name: 12C23
• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Purified Mouse Recombinant protein of IGF-BP5
• Specificity: This antibody detects IGF-BP5.
  No cross activity to other IGFBPs.
• Formulation: PBS without preservatives or stabilizers
  State: Purified
  State: Lyophilized (0.2 µm filtered) purified Ig fraction
• Reconstitution Method: Restore with 200 µl sterile PBS and the final concentration is 500 µg/ml.
• Purification: Protein A/G Affinity Chromatography
• Database Link:
  Entrez Gene 16011 Mouse
• Background: IGFBP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFBP5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGFBP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development.
• Synonyms: IGF-binding protein 5, IGFBP-5, IBP5, IBP-5