Il1rl1 (Extracell. Dom.) Rat Monoclonal Antibody [Clone ID: 3F22]

CAT#: DM3563P

Il1rl1 (Extracell. Dom.) rat monoclonal antibody, clone 3F22, Purified

Specifications

Product Data

• Clone Name: 3F22
• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Purified Mouse Recombinant IL-1 R4 extracellular doamin
• Specificity: This antibody detects IL-1 R4.
• Formulation: Lyophilized from a 0.2 µm filtered solution in PBS
  State: Purified
  State: Lyophilized purified Ig fraction
• Reconstitution Method: Restore with 200 µl sterile PBS and the final concentration is 500 µg/ml.
• Purification: Protein A/G Affinity Chromatography
• Gene Name: Mus musculus interleukin 1 receptor-like 1 (Il1rl1), transcript variant 1
• Database Link:
  Entrez Gene 17082 Mouse
• Background: ST2 is a member of the Toll-Interleukin 1 receptor (TIR) superfamily, expressed by mast cells and TH2 helper cells, but not by TH1 effector cells.
  The majority of TIR superfamily members, which includes the Interleukin-1 receptor (IL-1R1), Toll-like receptors (TLRs) and the cytosolic adaptor proteins MyD88, TIRAP, Trif and TRAM, initiate innate immunity through the ultimate activation of the transcription factor NF-kappaB and are inducers of the inflammatory response. In contrast ST2, which itself is unable to activate NF-kappaB, has been identified as a negative regulator of IL-1R1 and TLR4 signaling by sequestering MyD88 and TIRAP, in line with its role as a crucial receptor in TH2-cell mediated responses.
• Synonyms: Interleukin-1 receptor-like 1, DER4, FIT-1, MGC32623