IL21 Receptor (IL21R) (Extracell. Dom.) Rat Monoclonal Antibody [Clone ID: 7F27]

CAT#: DM3577P

IL21 Receptor (IL21R) (Extracell. Dom.) rat monoclonal antibody, clone 7F27, Purified

Specifications

Product Data

• Clone Name: 7F27
• Applications: WB
• Recommended Dilution: Western Blot: 1/500 - 1/1000.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant protein of IL-21R extracellular domain.
• Specificity: This antibody detects IL-21R.
• Formulation: State: Purified
  State: Lyophilized purified Ig
• Reconstitution Method: Restore with 200µl sterile PBS and the final concentration is 500µg/ml.
• Purification: Protein A/G affinity chromatography
• Background: IL21 Receptor is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
• Synonyms: IL-21R, NILR, IL21 receptor