CD321 / JAM1 (Extracell. Dom.) Rat Monoclonal Antibody [Clone ID: 1M21]

CAT#: DM3580P

CD321 / JAM1 (Extracell. Dom.) rat monoclonal antibody, clone 1M21, Purified

Specifications

Product Data

• Clone Name: 1M21
• Applications: WB
• Recommended Dilution: Western Blot: 1/500 - 1/1000.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Recombinant protein of JAM-A extracellular domain
• Specificity: This antibody detects JAM-A.
• Formulation: Protein A/G affinity chromatography
  State: Purified
  State: Lyophilized purified Ig
• Reconstitution Method: Restore with 200µl sterile PBS and the final concentration is 500µg/ml.
• Background: Junctional Adhesion Molecule 1 (JAM1) seems to play a role in epithelial tight junction formation. It appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. JAM1 plays a role in regulating monocyte transmigration involved in integrity of the epithelial barrier. JAM1 is also involved in platelet activation.
• Synonyms: JAM-A, Platelet F11 receptor, F11R, JCAM, PAM1