TGF beta Receptor II (TGFBR2) (Extracell. Dom.) Rat Monoclonal Antibody [Clone ID: 6G11]

CAT#: DM3596P

TGF beta Receptor II (TGFBR2) (Extracell. Dom.) rat monoclonal antibody, clone 6G11, Purified

Specifications

Product Data

• Clone Name: 6G11
• Applications: WB
• Recommended Dilution: Western Blot (1/500-1/1000).
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Recombinant Mouse TGF-beta R2 extracellular domain
• Specificity: This antibody detects Mouse TGF-beta R2. Other species not tested.
• Formulation: PBS
  State: Purified
  State: Lyophilized (0.2 µm filtered) purified IgG fraction from Culture Supernatant
  Stabilizer: None
• Reconstitution Method: Restore with 200 µl sterile PBS and the final concentration is 500 µg/ml.
• Purification: Protein A/G Affinity Chromatography
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Background: A total of three members of the TGFβ family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFβs mediate their activity by high affinity binding to the type II receptor (TGFβ RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFβ-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFβ type I receptor proteins designated ALK-5 (TβR-1) and TSR-1, respectively.
• Synonyms: TGF-beta receptor type-2, TGF-beta receptor type II, TGF-beta type II receptor, TbetaR-II, TGFR-2