Havcr2 Rat Monoclonal Antibody [Clone ID: 6F46]

CAT#: DM3599P

Havcr2 rat monoclonal antibody, clone 6F46, Purified

Specifications

Product Data

• Clone Name: 6F46
• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Purified Mouse recombinant TIM-3
• Specificity: This antibody detects of TIM-3. It does not cross-react with Mouse TIM-1 and TIM-2.
• Formulation: PBS without preservatives or stabilizers
  State: Purified
  State: Lyophilized purified IgG fraction from cell culture supernatant
• Reconstitution Method: Restore with 200 µl sterile PBS and the final concentration is 500 µg/ml.
• Purification: Protein A/G Affinity Chromatography
• Database Link:
  Entrez Gene 171285 Mouse
• Background: TIM-3 has been identified as a Th1 specific marker initially due to expression on activated and polarized Th1 cells and absence on naïve T cells. It has also been found on CD8+ T cells, Th17, Tregs , monocytes and dendritic cells. As a transmemebrane protein, TIM-3 is also referred to as 'T cell immunoglobulin and mucin-like domain containing protein -3.' Enhanced surface expression on CD4+ and CD8+ cells in the CNS are indicative of disease in EAE, murine models of MS. TIM-3 mediated down regulation of Th1 immune responses and induction of immune tolerance illustrate a potential key role for TIM-3 in immunoregulation.
• Synonyms: TIMD-3, TIM3, TIM-3, T-cell membrane protein 3, HAVCR-2