Trem1 (Extracell. Dom.) Rat Monoclonal Antibody [Clone ID: 3C66]

CAT#: DM3602P

Trem1 (Extracell. Dom.) rat monoclonal antibody, clone 3C66, Purified

Specifications

Product Data

• Clone Name: 3C66
• Applications: IHC, WB
• Recommended Dilution: Western blotting: 1/500-1000.
  Immunohistochemistry on Frozen Sections: 1/50-100.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Purified Mouse Recombinant TREM-1 extracellular domain.
• Specificity: This antibody detects Mouse of TREM-1, but not TREM-2b in Western blotting.
• Formulation: PBS without preservatives or stabilizers
  State: Purified
  State: Lyophilized (0.2 µm filtered) purified Ig fraction from Culture Supernatant
• Reconstitution Method: Restore with 0.2 ml sterile PBS and the final concentration is 0.5 mg/ml.
• Purification: Affinity Chromatography on Protein A/G.
• Predicted Protein Size: 26 kDa (Predicted)
• Database Link:
  NP_067381.1
  Entrez Gene 58217 Mouse
• Background: TREM1 is also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. TREM1 is a Type I membrane protein that contains an immunoglobulin-like V-type domain. An alternatively spliced protein variant may be secreted. TREM1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes); TREM1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock.
• Synonyms: TREM-1