Plaur Rat Monoclonal Antibody [Clone ID: 7J34]

CAT#: DM3607P

Plaur rat monoclonal antibody, clone 7J34, Purified

Specifications

Product Data

• Clone Name: 7J34
• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Purified Mouse Recombinant uPAR
• Specificity: This antibody detects uPAR.
• Formulation: PBS
  State: Purified
  State: Lyophilized (0.2 μm filtered) purified IgG fraction of the Culture Supernatant
  Stabilizer: None
• Reconstitution Method: Restore with 200µl sterile PBS and the final concentration is 500µg/ml.
• Purification: Protein A/G Affinity Chromatography
• Database Link:
  Entrez Gene 18793 Mouse
• Background: uPAR (Urokinase plasminogen activator receptor) is a glycoprotein I anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum beta globulin plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.
• Synonyms: U-PAR, PLAUR, MO3