GZMB

CAT#: DP105-05

Rabbit polyclonal anti-Granzyme B (GZMB) antibody, Purified

Product Images

Formalin fixed paraffin embedded human tonsil stained with Granzyme B antibody. DP105

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A synthetic peptide from the N-terminus of human Granzyme B.
• Formulation: 10 mM Citrate Buffer, pH 6.0 containing Sodium Azide as preservative.
• Purification: Liquid purified Ig fraction. Purified
• Conjugation: Unconjugated
• Predicted Protein Size: ~25.5 kDa
• Gene Name: granzyme B
• Database Link:
  NP_004122
  Entrez Gene 14939 MouseEntrez Gene 171528 RatEntrez Gene 3002 Human
  UniProt ID P10144
• Background: Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned. Human granzymes B is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. This antibody is useful in the localization of granzyme B containing lytic granules and for the characterization of activated CTLs or NK cells.
• Synonyms: C11; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; Fragmentin-2; Granzyme-2; GRB; HLP; SECT

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Allograft rejection, Autoimmune thyroid disease, Graft-versus-host disease, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus