Her2 (ERBB2) Rabbit Polyclonal Antibody

CAT#: DP2012

Her2 (ERBB2) rabbit polyclonal antibody, Azide Free


USD 405.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications ELISA, WB
Recommended Dilution ELISA.
Western Blot.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant Human Herstatin.
The immunization antigen (43.4 kda) is a protein containing 397 AA of recombinant Human Herstatin and one extra AA, N-terminal methionin (highlighted)
Specificity This Antibody reacts to Herstatin.
Formulation 0.05 M Phosphate buffer, 0.1 M NaCl, pH 7.2 without preservatives.
State: Azide Free
State: Lyophilized purified IgG fraction.
Reconstitution Method Add 0.05 ml of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
Concentration lot specific
Storage Store lyophilized protein (preferably in a desiccator) at -20°C and in aliquots at -80°C.
Reconstituted protein can be stored at 4°C for a limited period of time; it does not show decline in activity after two weeks at 4°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 2
Background HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of an alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.
Synonyms HER-2, NEU, p185erbB2, NGL, c-erbB-2, MNL19
Reference Data
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Calcium signaling pathway, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.