PROX1 (C-term) Rabbit Polyclonal Antibody

CAT#: DP3501PS

PROX1 (C-term) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Suitable for Western Blot and Immunohistochemistry on Frozen and Paraffin Sections.
• Reactivities: Fish, Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide corresponding to the Homeobox domain of Prox1.
• Specificity: This antibody is reactive with Prox-1.
  It will be a useful tool to study lymphatic vessel density in and around human tumors.
  It will detect Prox-1 in the nucleus of lymphatic endothelial cells.
• Formulation: State: Purified
  State: Liquid purified Ig fraction
• Storage: Store the antibody (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens prospero homeobox 1 (PROX1), transcript variant 2
• Database Link:
  Entrez Gene 19130 MouseEntrez Gene 305066 RatEntrez Gene 5629 Human
• Background: The homeobox gene Prox-1 was originally cloned by homology to the Drosophila melanogaster gene prospero. Prox-1 is expressed in a subpopulation of endothelial cells which by budding and sprouting, give rise to the lymphatic system. Prox-1-deficient homozygous mice have unaffected vasculogenesis and angiogenesis, but liver and lymphatics do not develop. Human Prox-1 gene has been mapped to chromosome 1q32.2-q32.3, and its product shows 94% similarity to the chicken protein. The conserved structure and expression pattern of the Prox-1 gene imply that it may play the same roles in humans as in other vertebrates. The human Prox-1 gene is most actively expressed in the developing lens. Anti-Prox-1 antibodies provide a highly specific marker of lymphatic endothelial cells.
• Synonyms: PROX1

Reference Data

• Protein Families: Embryonic stem cells, ES Cell Differentiation/IPS