Cxcl10 Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | ELISA, FN, WB |
Recommended Dilution | Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of Mouse IP-10 (100 ng/ml), a concentration of 10.0 µg/ml of this antibody is required. Sandwich ELISA: To detect Mouse IP-10 by Sandwich ELISA (using 100 µl/well antibody solution), a concentration of 0.5-2.0 µg/ml of this antibody is required. This Affinity purified antibody, in conjuction with Biotin conjugated anti Mouse IP10 antibody (cat. PP1083B) as a Detection antibody, allows the detection of at least 0.2-0.4 ng/well of recombinant Mouse IP-10. Western Blot: To detect Mouse IP-10 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant Mouse IP-10 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. |
Reactivities | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Highly pure (>98%) E.coli derived recombinant Murine IP-10. |
Specificity | Reacts with Interferon-gamma Inducible Protein. |
Formulation | PBS, pH 7.2 without preservatives. State: Aff - Purified State: Lyophilized purified Ig fraction. |
Reconstitution Method | Restore in sterile water to a concentration of 0.1-1.0 mg/ml. |
Purification | Affinity Chromatography using an immobilized Murine IP-10 Matrix |
Database Link | |
Background | Interferon-gamma-inducible 10 kD protein (IP-10), is a CXC chemokine with chemoattractant properties for CD4-positive T cells and inhibits early normal and leukemic hemopoietic progenitor proliferation. IP-10 is produced by a wide variety of cell types ranging from neutrophils and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV encephalitis, cutaneous T cell lymphoma, chronic hepatitis and acute anterior uveitis. Various observations strongly suggest a role for the CXC chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis. |
Synonyms | C-X-C motif chemokine 10, Small-inducible cytokine B10, Gamma-IP10, INP10, SCYB10 |
Note | Centrifuge vial prior to opening! |
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