IL22 Rabbit Polyclonal Antibody

CAT#: PP1224P2

IL22 rabbit polyclonal antibody, Aff - Purified


USD 355.00

2 Weeks*

Size
    • 100 ug

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Other products for "IL22"

Specifications

Product Data
Applications ELISA, WB
Recommended Dilution Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of Human IL-22 (50.0 ng/ml), a concentration of 1.25 µg/ml of this antibody is required.
Sandwich ELISA: To detect Human IL-22 by Sandwich ELISA (using 100 µl/well antibody solution) a concentration of 0.5-2.0 µg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated anti-Human IL22 (PP1224B1 or PP1224B2) as detection antibody, allows the detection at least 0.2-0.4 ng/well of recombinant Human IL-22.
Western blot: To detect Human IL-22 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant Human IL-22 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Highly pure (>98%) E.coli derived recombinant Human Interleukin-22 (hIL-22).
Specificity Recognizes Interleukin-22 (IL-22).
Formulation PBS, pH 7.2 without preservatives.
State: Aff - Purified
State: Lyophilized (sterile filtered) purified Ig fraction.
Reconstitution Method Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
Purification Affinity Chromatography employing immobilized Human IL-22 matrix.
Gene Name Homo sapiens interleukin 22 (IL22)
Background IL22 is a cytokine structurally related to IL10 and is upregulated in activated T cells. IL22 signals through a receptor complex that includes CRF2-4 and a new member of the class II cytokine receptor family (also known as the interferon receptor family), IL22R. CRF2-4 has previously been demonstrated to be a functional component of the IL-10 signaling complex.
IL22 is able to suppress IL4 production; this may have therapeutic potential, particularly in the treatment of asthma.
Synonyms IL-22, ILTIF, Cytokine Zcyto18
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.