NPY2R (N-term + C-term) Rabbit Polyclonal Antibody

CAT#: RA14136-50

NPY2R (N-term + C-term) rabbit polyclonal antibody, Serum

Product Images

Figure 1. NPY Y2R staining of Rat cortex using Cy3-conjugated Donkey anti-Rabbit secondary antibodies (Red color) and DAPI (Blue) as a nuclear counterstain.

Specifications

Product Data

• Applications: IF, IHC
• Recommended Dilution: Immunohistochemistry: 1/100-1/300.
  Immunofluorescence.
  To improve staining intensity, it may be necessary to employ HRP-DAB (Vector Elite ABC kit) detection or enhance Fluorescence signal using Tyramide Signal Amplification procedure.
• Reactivities: Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: C) GAEDENQTVEVKVE-NH2 and (C) TDFSEATNV-COOH
• Specificity: Recognizes NPY Y2 Receptor at C/N Terminus.
• Formulation: PBS containing 0.05% Sodium Azide as preservative
  State: Serum
  State: Liquid Whole Serum.
• Storage: Store undiluted at 2-8°C for one month or (in alqiuots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens neuropeptide Y receptor Y2 (NPY2R)
• Database Link:
  Entrez Gene 18167 MouseEntrez Gene 66024 Rat
• Background: Neuropeptide Y (NPY) receptors are members of a G protein coupled receptor superfamily and they mediate a variety of physiological responses including feeding and vasoconstriction. The endogenous ligands of NPY receptors are a family of structurally related peptides, including NPY, peptide YY (PYY), and pancreatic polypeptide (PP). Increased activity of NPY and its receptors, Y1R, Y2R, and Y5R has been found in the brain in many forms of experimental obesity. Furthermore, several association studies have supported the association between NPY2R and obesity.
• Synonyms: NPY2-R, NPY-Y2 receptor, Y2 receptor, Neuropeptide Y receptor 2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction