Integrin alpha 6 (ITGA6) Rat Monoclonal Antibody [Clone ID: NKI-GoH3]

CAT#: SM038PS

Integrin alpha 6 (ITGA6) rat monoclonal antibody, clone NKI-GoH3, Purified

Specifications

Product Data

• Clone Name: NKI-GoH3
• Applications: FC, IHC, IP
• Recommended Dilution: Flow Cytometry.
  Immunohistochemistry on Frozen Sections.
  Recommended Positive Control Tissue: Human Tonsil.
  Immunoprecipitation.
• Reactivities: Canine, Human, Monkey, Mouse, Porcine, Sheep
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: BALB/c mouse mammary tumour cells.
  Spleen cells from immunised Sprague-Dawley rats were fused with cells of the SP2/0 mouse myeloma cell line.
• Specificity: This antibody recognises the CD49f-antigen, (VLA-6 alpha-chain). This antibody reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1).
  In Immunohistology this clone reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytiotrophoblasts. Platelet VLA-6 functions as a laminin receptor.
  This clone has been reported to inhibit platelet adhesion to Laminin. (3)
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit alpha 6
• Database Link:
  Entrez Gene 3655 Human
• Background: CD49f can form distinct complexes with either the CD29-antigen (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells.
• Synonyms: Integrin alpha-6, VLA-6, VLA6