Tnfrsf4 Rat Monoclonal Antibody [Clone ID: OX-86]

CAT#: SM055PS

Tnfrsf4 rat monoclonal antibody, clone OX-86, Purified

Specifications

Product Data

• Clone Name: OX-86
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry: Use 10 µl of 1/10-1/50 diluted antibody to label 1x10e6 cells in 100 µl.
  Immunohistochemistry on Frozen Sections.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: CHO cells transfected with murine OX40.
  Spleen cells from immunised AO rats were fused with cells of the mouse NS1 myeloma cell line.
• Specificity: This antibody recognises OX40 (CD134), a cell surface antigen expressed only by activated T lymphocytes.
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified IgG fraction.
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography on Protein G
• Database Link:
  Entrez Gene 22163 Mouse
• Background: The OX40 receptor is also known as CD134, ACT35, and tumour necrosis factor receptor superfamily member 4. This receptor is expressed on activated CD4+ and CD8+ T cells and B cells. The OX40 receptor binds to the OX40 ligand to provide a co-stimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, imply that these interactions are important in the pathogenesis of some autoimmune diseases.
• Synonyms: TNFRSF4, TXGP1L, ACT35 antigen, OX40L receptor