Cd19 Rat Monoclonal Antibody [Clone ID: 1D3]

CAT#: SM1050P

Cd19 rat monoclonal antibody, clone 1D3, Purified


USD 165.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 1D3
Applications FC, FN, IHC, IP
Recommended Dilution Flow cytometry.
Immunoprecipitation.
Immunohistochemistry (frozen sections).
Functional application: This antibody can induce down-regulation of CD19, affecting the proportions of B cell subpopulations.
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen Mouse CD19-transfected cell line
Specificity This antibody detects CD19, 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
Formulation Phosphate buffered saline (PBS)
State: Purified
State: Liquid Ig fraction
Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration 1.0 mg/ml
Purification Protein-G affinity chromatography (> 95% pure by SDS-PAGE)
Background CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Synonyms Leu-12, B-cell marker
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.