CD7 Mouse Monoclonal Antibody [Clone ID: LT7]

CAT#: SM1074B

CD7 mouse monoclonal antibody, clone LT7, Biotin

Product Images

Staining of human peripheral blood lymphocytes with Mouse Anti Human CD7 Antibody -Biotin conjugated

Specifications

Product Data

• Clone Name: LT7
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry: Use 10 µl of neat antibody label 10⁶ cells in 100 µl.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Normal human peripheral blood lymphocytes.
  Spleen cells from immunised BALB/c mice were fused with cells of the X63.653 mouse myeloma cell line.
• Specificity: This antibody is a single chain cell surface glycoprotein of 40kD, expressed by T cells, NK cells and thymocytes.
  CD7 is also expressed by tumour cells in some cases of acute myeloid leukaemia.
• Formulation: PBS, pH 7.4
  Label: Biotin
  State: Liquid purified IgG fraction.
  Stabilizer: 1% BSA
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Biotin
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 924 Human
• Background: CD7 is a 40 kDa transmembrane, single-chain glycoprotein, which is a member of the immunoglobulin superfamily. CD7 is expressed by the majority of thymocytes and mature T cells, NK cells and pre-B cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.
  The function of CD7 is not yet known although cross-linking of CD7 with antibodies induces a T cell transmembrane calcium flux and CD7 expression is induced by ionomycin. The CD7 molecule has been reported to be the receptor for the IgM-Fc portion (FcR mu) on the surface of T cells.
• Synonyms: GP40, TP41, Leu-9