CD45 (PTPRC) (CD45RA) Mouse Monoclonal Antibody [Clone ID: MEM-56]

CAT#: SM1115B

CD45 (PTPRC) (CD45RA) mouse monoclonal antibody, clone MEM-56, Biotin


USD 270.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name MEM-56
Applications FC
Recommended Dilution Flow cytometry (1/120).
Reactivities Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Human thymocytes and T lymphocytes
Specificity The antibody reacts with CD45RA, a 205-220 kDa single chain type I glycoprotein, variant of CD45 (CD45RA isoform). CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes.
Formulation Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Label: Biotin
State: Liquid purified Ig fraction
Label: Conjugated with -LC-NHS under optimum conditions. The reagent is free of unconjugated biotin
Concentration lot specific
Conjugation Biotin
Storage Store the antibody undiluted at 2 - 8 °C. DO NOT FREEZE!
Stability Shelf life: one year from despatch.
Background CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on nave T cells and normal plasma cells.
Synonyms PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.