Integrin alpha 6 (ITGA6) Mouse Monoclonal Antibody [Clone ID: 450-30A]

CAT#: SM1140FT

Integrin alpha 6 (ITGA6) mouse monoclonal antibody, clone 450-30A, FITC


USD 190.00

5 Days*

Size
    • 25 ug

Product Images

Specifications

Product Data
Clone Name 450-30A
Applications FC
Recommended Dilution Flow Cytometry: Use 10 µl of neat antibody to label 10e6 cells in 100 µl.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Alpha 6 beta 4 Integrin purified from A431 cells
Specificity This antibody recognizes the human VLA-6 cell surface antigen, also known as the a6 Integrin and as CD49f.
CD49f is expressed by platelets, weakly by monocytes and by a subset of lymphocytes.
Formulation PBS, pH 7.4
Label: FITC
State: Liquid purified IgG fraction
Stabilizer: 1% BSA
Preservative: 0.09% Sodium Azide
Label: Fluorescein Isothiocyanate Isomer 1
Concentration lot specific
Purification Affinity chromatography on Protein G
Conjugation FITC
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name integrin subunit alpha 6
Background Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Integrin alpha 6 complexes are receptors for laminins, which are components of basement membranes. Integrin alpha 6 complexes may play an important role in embryogenesis.
Synonyms Integrin alpha-6, VLA-6, VLA6
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.