CD59 Mouse Monoclonal Antibody [Clone ID: MEM-43]

CAT#: SM1145FT

CD59 mouse monoclonal antibody, clone MEM-43, FITC

Product Images

Staining of KG1 lymphocytes with Mouse Anti Human CD59-FITC (SM1145FT).

Specifications

Product Data

• Clone Name: MEM-43
• Applications: FC
• Recommended Dilution: Flow Cytometry (Neat).
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: The antigen binds to C8 and C9 and inhibits assembly of the complement membrane attack complex.
• Formulation: BS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
  Label: FITC
  State: Liquid purified IgG fraction.
  Label: Fluorescein Isothiocyanate Isomer 1
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A.
• Conjugation: FITC
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  This product is photosensitive and should be protected from light.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 966 Human
• Background: CD59 is an LY6 like protein expressed in human lymphoid cells (haemapoietic and non- haemapoietic cells), regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
  CD59 is an 18-20kD GPI anchored single chain glycoprotein, expressed by virtually all cell types, including leucocytes, platelets and erythrocytes.
• Synonyms: MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21, MACIF, MAC-IP, MIRL, HRF20, HRF-20