CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: SN6]

CAT#: SM1177FT

CD105 (ENG) mouse monoclonal antibody, clone SN6, FITC

Product Images

Staining of KG1 cells with mouse-anti-human CD105-FITC antibody

Specifications

Product Data

• Clone Name: SN6
• Applications: FC
• Recommended Dilution: Flow Cytometry: Use 10 µl of neat antibody to label 10⁶ cells in 100 µl.
• Reactivities: Equine, Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Partially purified cell membrane antigens from fresh leukaemia cells.
  Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3/NS1/1-Ag4-1 myeloma cell line
• Specificity: SM1177F recognizes the CD105 cell surface antigen.
• Formulation: PBS
  Label: FITC
  State: Liquid purified IgG fraction
  Stabilizer: 1% BSA
  Preservative: 0.09% Sodium Azide
  Label: Fluorescein Isothiocyanate Isomer 1
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G from tissue culture supernatant.
• Conjugation: FITC
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  This product is photosensitive and should be protected from light.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: endoglin
• Database Link:
  Entrez Gene 2022 Human
• Background: CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
  CD105 is a glycoprotein homodimer of 95 kD subunits.
  CD105 is expressed by endothelial cells, activated monocytes and some leukaemia cells.
• Synonyms: ENG, END, HHT1, ORW, ORW1