Factor I (CFI) Mouse Monoclonal Antibody [Clone ID: OX-21]

CAT#: SM1376B

Factor I (CFI) mouse monoclonal antibody, clone OX-21, Biotin

Specifications

Product Data

• Clone Name: OX-21
• Applications: ELISA, FC, IP, R, WB
• Recommended Dilution: ELISA: 1/40000 (Plates were coated with 2 ug/ml purified Factor I, and HRPO-Streptavidin was used for detection).
  Western Blot.
  Flow Cytometry.
  Immunoprecipitation.
  Radioimmunoassay.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human complement Factor I.
  Donor: Immunized FI cross DBA/2 x BALB/c mouse spleen cells
  Fusion Partner: NS-1 mouse myeloma
• Specificity: Anti-human factor I (C3b inactivator) monoclonal antibody clone OX-21 recognizes human complement protein factor I.
  Factor I has two polypeptide chains, 56kD and 38kD. This antibody detects only the 56kD chain.
  This clone has been reported not to cross react with Rat.
• Formulation: PBS
  Label: Biotin
  State: Liquid purified IgG fraction
  Stabilizer: EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Conjugation: Biotin
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement factor I (CFI), transcript variant 2
• Database Link:
  Entrez Gene 3426 Human
• Background: Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement protein breakdown products: Factor H, CR1 and MCP are required for C3b cleavage and C4bp or CR1 for C4b cleavage.
• Synonyms: CFI, IF, KAF, AHUS3, C3BINA, C3b-INA

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades