Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone ID: 2C7]

CAT#: SM1475R

Myeloperoxidase (MPO) mouse monoclonal antibody, clone 2C7, PE


USD 495.00

5 Days*

Size
    • 100 Tests

Product Images

Specifications

Product Data
Clone Name 2C7
Applications FC
Recommended Dilution Flow Cytometry: Use 10 µl of neat antibody to label 10e6 cells in 100 µl (Membrane permeabilisation is required).
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human Myeloperoxiase. 
Spleen cells from immunised mice were fused with cells of the mouse X63 AG8-653 myeloma cell line.
Specificity This antibody recognizes Myeloperoxidase (MPO).
It may be used for the Flow Cytometric detection of Myeloid cells following membrane permeablisation. 
Negative Species: Rat.
Formulation PBS
Label: PE
State: Lyophilized purified IgG fraction
Stabilizer: 1% BSA, 5% Sucrose
Preservative: 0.09% Sodium Azide
Label: R. Phycoerythrin (RPE)
Reconstitution Method Restore with 1 ml distilled water
Purification Affinity Chromatography on Protein G
Conjugation PE
Storage Store undiluted Prior to and following reconstitution at 2-8°C.
DO NOT FREEZE!
This antibody is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Gene Name myeloperoxidase
Background MPO is an important component of azurophilic granules in neutrophils.
Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 - 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW 150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.
Synonyms MPO
Reference Data

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