IL2 Mouse Monoclonal Antibody [Clone ID: 4F12]

CAT#: SM1540A

IL2 mouse monoclonal antibody, clone 4F12, Azide Free

Specifications

Product Data

• Clone Name: 4F12
• Applications: ELISA, FN
• Recommended Dilution: ELISA: 5-10 µg as capture antibody.
  Functional Assays: 2-20 µg/ml.
• Reactivities: Birds, Chicken, Mammalian
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant Chicken IL-2.
• Specificity: This antibody SM1540A recognises natural and recombinant IL-2 expressed in either E.coli or CHO cells.
  Clone 4F12 neutralises the proliferative activity of rchIL-2 and recognises a different epitope to Clone 10E7 product code (Cat.-No SM1539A).
  This antibody can be used as the Neutralising antibody for recombinant Chicken IL-2 bioassays (See Product code SA028).
• Formulation: PBS without preservatives
  State: Azide Free
  State: Liquid purified IgG fraction
  Stabilizer: None
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Storage: Store the antibody undiluted at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens interleukin 2 (IL2)
• Database Link:
  Entrez Gene 3558 Human
• Background: Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.
• Synonyms: IL-2, TCGF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus