CD5 Mouse Monoclonal Antibody [Clone ID: FE1.1B11]

CAT#: SM1584F

CD5 mouse monoclonal antibody, clone FE1.1B11, FITC


USD 560.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name FE1.1B11
Applications FC
Recommended Dilution Flow Cytometry: Neat - 1/10; Use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
Reactivities Feline
Host Mouse
Isotype IgG1
Clonality Monoclonal
Specificity This antibody recognises CD5, a 67kD cell surface glycoprotein expressed by peripheral T lymphocytes and thymocytes.
Formulation PBS containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
Label: FITC
State: Liquid purified IgG
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.1 mg/ml
Purification Affinity chromatography on Protein G
Conjugation FITC
Background CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
Synonyms LEU1, LEU-1, Ly-1, Lyt-1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.