Estrogen Receptor 1 (ESR1) Mouse Monoclonal Antibody [Clone ID: 6F11]

CAT#: SM1715T

Estrogen Receptor 1 (ESR1) mouse monoclonal antibody, clone 6F11, Supernatant


USD 260.00

5 Days*

Size
    • 100 ul

Product Images

Specifications

Product Data
Clone Name 6F11
Applications IHC
Recommended Dilution Immunohistochemistry on Frozen Sections (1/40-1/60): Zambonis fixative recommended for best results.
Immunohistochemistry on Paraffin Sections (1/40-1/80): Rquires Antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.
Recommended Positive Control: Breast carcinoma.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant Human Eestrogen Receptor (alpha form).
Specificity This antibody recognises the Estrogen Receptor alpha chain.
The oestrogen receptor status of breast cancer tissues is an important parameter in determining prognosis and response to therapy.
Formulation State: Supernatant
State: Liquid Tissue Culture Supernatant containing 0.09% Sodium Azide.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Estrogen Receptor alpha is a 65 kDa protein and a member of the steroid family of nuclear receptors. Estrogen Receptor alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, Estrogen Receptor alpha can positively or negatively regulate gene transcription.
Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Estrogen Receptors play an important role in regulating mammary gland growth and differentiation. Breast tumors that are ER positive may also show a more favorable response to anti-estrogen therapies
Synonyms ER alpha, Estradiol receptor, ESR1, ESR, NR3A1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.