c Kit (KIT) Mouse Monoclonal Antibody [Clone ID: 104D2]
Specifications
Product Data | |
Clone Name | 104D2 |
Applications | FC |
Recommended Dilution | Indirect immunofluorescence analysis by Flow cytometry. |
Reactivities | Bovine, Human, Primate |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | MOLM-1 megakaryocytic cells |
Specificity | This antibody detects extracellular part of CD117 / c-Kit protooncogen. |
Formulation | Phosphate buffered saline (PBS) Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4 Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin. |
Concentration | lot specific |
Conjugation | Biotin |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells. |
Synonyms | SCFR, KIT |
Reference Data |
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