c Kit (KIT) Mouse Monoclonal Antibody [Clone ID: 104D2]

CAT#: SM1720R

c Kit (KIT) mouse monoclonal antibody, clone 104D2, PE

Specifications

Product Data

• Clone Name: 104D2
• Applications: FC
• Recommended Dilution: Flow Cytometry: Use 5 µl of Neat antibody to label 10⁶ cells in 100 µl.
• Reactivities: Bovine, Human, Monkey
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: MOLM-1 Megakaryocyte cell line.
• Specificity: This antibody recognises the CD117 cell surface antigen.
  Functionally CD117 is a receptor for stem cell factor, and has receptor tyrosine kinase activity.
• Formulation: PBS
  Label: PE
  State: Liquid purified IgG fraction
  Stabilizer: 0.2% BSA
  Preservative: 0.09% Sodium Azide
  Label: R. Phycoerythrin (RPE)
• Conjugation: PE
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
  
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 3815 Human
• Background: c-kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-kit ligand to c-kit initiate autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol-3-kinase, src family kinases, and STATs. The role of c-kit includes maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-kit has been proposed to play a functional role, and becomes target molecule for drug development.
• Synonyms: SCFR, KIT