CD44 Rat Monoclonal Antibody [Clone ID: 1OD1]

CAT#: SM1731P

CD44 rat monoclonal antibody, clone 1OD1, Purified

Specifications

Product Data

• Clone Name: 1OD1
• Applications: ELISA, IHC, WB
• Recommended Dilution: Immunohistochemistry on frozen sections.
  ELISA.
  Western Blot.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: GST-CD44v4 fusion protein. Spleen cells from immunised rats were fused with cells of the SP2/0 myeloma cell line.
• Specificity: This antibody specifically recognises an epitope encoded by exon v4 on the variant portion of CD44.
• Formulation: PBS containing 0.01% Thimerosal
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: Affinity chromatography on Protein G
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Background: CD44 is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
  CD44 variant 4 may influence the progression of colorectal cancer.
• Synonyms: CD44, LHR, MDU2, MDU3, MIC4, Phagocytic glycoprotein I, PGP-1, HUTCH-I, Extracellular matrix receptor-III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, Hermes antigen, Hyaluronate receptor, Heparan sulfate proteoglycan, Epican, CDw44